Synthesis of cyclic and acyclic nucleoside analogues having a thiophene or dihydrothiophene ring fused to the d side of an uracil

A novel approach to unsaturated acyclic

A novel approach to unsaturated acyclic nucleoside analogues and the first synthesis of d4T by ring closure metathesis

✍ David Ewing; Virginie Glaçon; Grahame Mackenzie; Denis Postel; Christophe Len 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 55 KB

enyloxy]prop-2-enyl}cytosine have been prepared in good yield from uridine and 5-methyluridine by periodate cleavage followed by a double Wittig reaction which introduces two vinyl groups. The thymine derivative underwent ring closure metathesis to give a novel synthesis of d4T.