Synthesis of Conformationally Constrained 5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine Inhibitors of Farnesyltransferase
β Scribed by Dinsmore, Christopher J.; Zartman, C. Blair; Baginsky, Walter F.; O'Neill, Timothy J.; Koblan, Kenneth S.; Chen, I-Wu; McLoughlin, Debra A.; Olah, Timothy V.; Huff, Joel R.
- Book ID
- 111674160
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 56 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1523-7060
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Using a convenient and practical route we report the preparation of a series of rigid surrogates of amino acids and dipeptides for application within constrained peptide analogues, and for employment as input for combinatorial science. These substituted 2-oxo-1azabicycloalkane amino acids have the p