Synthesis of conduritol, conduramine, and validoxylamine analogs from tetrahydronaphthalene-cis-diol
✍ Scribed by Marie-Christine Lallemand; Michel Desjardins; Stanley Freeman; Tomas Hudlicky
- Book ID
- 104258127
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 216 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract 2‐Amino‐1,2,3,4‐tetrahydronaphthalene‐6,7‐diol (**2**; 6,7‐ADTN) was synthesized starting from naphthalene‐2,3‐diol in seven steps and with an overall yield of 44%. Methylation of naphthalene‐2,3‐diol with dimethyl sulfate, followed by __Friedel____Crafts__ acylation with AcCl, gave 2‐
YF Diene (l), available by microbial oxidation of benzene, undergoes react on with singlet oxygen to yield endoperoxides (2) and (3); reduction or rearrangement of these compounds gives conduritols ( 5) and ( 6) or dehydroconduritols ( 8) and ( 9), respectively.