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Synthesis of cleonine, amino(1-hydroxycyclopropyl)acetic acid, a novel amino acid contained in cleomycin

✍ Scribed by Kuniki Kato; Tomohisa Takita; Hamao Umezawa

Publisher: Elsevier Science
Year: 1980
Tongue: French
Weight: 99 KB
Volume: 21
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)71156-7

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✦ Synopsis

The synthesis of cleonine, amino(l-hydroxycyclopropyl)acetic acid, a novel amino acid contained in cleomycin, a new bleomycin-phleomycin group antibiotic, is described. Cleomycin (l-a) is a new family of bleomycin-phleomycin group antibiotics and is different from bleomycin (l-b) only in its threonine moiety.' A novel amino acid designated cleonine, amino(l-hydroxycyclopropyl)acetic acid (Z), is located in the place of the threonine of bleomycin

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