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Synthesis of chromeno[2′,3′:4,5]imidazo[2,1-a]isoquinolines via a novel domino reaction of isoquinoline-derived immonium salts. Scope and limitations

✍ Scribed by Leonid G. Voskressensky; Alexey A. Festa; Ekaterina A. Sokolova; Alexey V. Varlamov


Book ID
116909442
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
403 KB
Volume
68
Category
Article
ISSN
0040-4020

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The 1,4-dipolar intermediate generated by the addition of isoquinoline to dimethyl acetylenedicarboxylate is trapped by 1,2-and 1,4-benzoquinones to afford spiro[1,3]oxazino[2,3-a]isoquinoline derivatives in high yields.