Synthesis of chiral N-protected α-amino aldehydes by reduction of N-protected N-carboxyanhydrides (UNCAs)
✍ Scribed by Jean-Alain Fehrentz; Catherine Pothion; Jean-Christophe Califano; Albert Loffet; Jean Martinez
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 283 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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N-protected cx-alkyl--t-amino-13-keto-esters were synthesized from the corre,q~nding Nurethane prolected N-carboxyanhydride (UNCAs) by reaction with lithium enolates in fairly good yields. These compounds are candidates for mimicking the transition state analogue in enzyme inhibitors. They constitut
A facile synthesis of a wide variety of N-protected p-amino akobol derivatives under mild conditions is described. N-umtbane proceded amino acid N-carboxyanhydrides (UNCAs) were used as starting ma&al and reduced into the correspooding akohols with the appropriate hydride, sodium borobydride. The re