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Synthesis of N-urethane protected α-alkyl-γ-amino-β-keto-esters from urethane N-carboxyanhydrides (UNCAs)

✍ Scribed by Marielle Paris; Jean-Alain Fehrentz; Annie Heitz; Jean Martinez

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 214 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00026-4

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✦ Synopsis

N-protected cx-alkyl--t-amino-13-keto-esters were synthesized from the corre,q~nding Nurethane prolected N-carboxyanhydride (UNCAs) by reaction with lithium enolates in fairly good yields. These compounds are candidates for mimicking the transition state analogue in enzyme inhibitors. They constitute, however, interesting and diverse building blocks for using in combinatorial chemistry.

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