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Synthesis of chiral ligands containing the N-(S)-α-phenylethyl group and their evaluation as activators in the enantioselective addition of Et2Zn to benzaldehyde

✍ Scribed by Virginia M. Mastranzo; Ericka Santacruz; Gabriela Huelgas; Evelyn Paz; Martha V. Sosa-Rivadeneyra; Sylvain Bernès; Eusebio Juaristi; Leticia Quintero; Cecilia Anaya de Parrodi


Book ID
108284098
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
206 KB
Volume
17
Category
Article
ISSN
0957-4166

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Two generally applicable routes for the synthesis of chiral amino alcohols embodying the bispidine framework have been developed. In linear route A the bispidine framework is built up successively from chiral primary amines via intermediate formation of a piperidinone and a bispidinone. In convergen