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Synthesis of chiral fused heterocyclic compounds containing 1,2,4-triazole ring

✍ Scribed by Haoxin Shi; Zhongyi Wang; Haijian Shi

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
31 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A series of new chiral (S)‐3‐ary1‐6‐pyrrolidin‐2‐yl‐[1,2,4]triazolo[3,4‐b]thiadiazole (II~1‐5~), (S)‐1‐(3‐aryl‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazol‐6‐yl)‐ethylamine (II~6‐8~) and (S)‐1,2‐bis(3‐aryl‐[1,2,4]triazolo‐[3,4‐b][1,3,4]thiadiazol‐6‐yl)‐ethylamine (II~9‐11~) were prepared by the condensation of 3‐aryl‐4‐amino‐5‐mercapto‐1,2,4‐triazoles with different L‐amino acids in the presence of phosphorus oxychloride and evaluated for their antibacterial activity.

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Design and synthesis of diheterocyclic compounds containing tetrazolinone and 1,2,4-triazole
✍ Yan-Ping Luo; Long Lin; Guang-Fu Yang 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 489 KB

## Abstract magnified image A novel series of 1‐(4‐chlorophenyl)‐4‐{[5‐(alkylthio)‐4‐phenyl‐4__H__‐1,2,4‐triazol‐3‐yl]methyl}‐1,4‐dihydro‐5__H__‐tetrazol‐5‐ones **6a‐y** were synthesized in good to excellent yields and their structures were identified by ^1^H nmr, ^13^C nmr, ms and elemental analy