Fused 1,2,4-triazole heterocycles. IV. Synthesis of four new heterocyclic ring systems of [1,2,4]triazolo[1,3]thiazinoquinolines
✍ Scribed by Ferenc Kóródi; József Jekõ; Zoltán Szabó
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1997
- Tongue
- English
- Weight
- 485 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
Syntheses of 5__H__‐[1,2,4]triazolo[5′,1′:2,3][1,3]thiazino[5,4‐c]quinolines 8, 5__H__‐[1,2,4]triazolo[3′,4′:2)3][1,3]thiazino[5,4‐c]quinolines 9, 5__H__‐[1,2,4]triazolo[5′,1′:2,3][1,3]thiazino[5,6‐c]quinolines 14 and 5__H__‐[1,2,4]triazolo[3′,4′:2,3][1,3]thiazino[5,6‐c]quinolines 15 are described starting from 4‐chloro‐3‐chloromethylquinaldine (4) and 1,2,4‐triazole‐5‐thiols 5 taking advantage of different reactivity of the chlorine atoms of 4 under different reaction conditions. The structures of products 8, 9, 14 and 15 and the intermediates leading to them were confirmed by desulfurization, unequivocal syntheses and nmr spectroscopy as well.
📜 SIMILAR VOLUMES
## Abstract A series of new chiral (__S__)‐3‐ary1‐6‐pyrrolidin‐2‐yl‐[1,2,4]triazolo[3,4‐__b__]thiadiazole (II~1‐5~), (__S__)‐1‐(3‐aryl‐[1,2,4]triazolo[3,4‐__b__][1,3,4]thiadiazol‐6‐yl)‐ethylamine (II~6‐8~) and (__S__)‐1,2‐bis(3‐aryl‐[1,2,4]triazolo‐[3,4‐__b__][1,3,4]thiadiazol‐6‐yl)‐ethylamine (II~
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