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Synthesis of chiral diaza 18-crown-6 ethers from chiral amines and molecular recognition of potassium and sodium salts of amino acids

✍ Scribed by N. Demirel; Y. Bulut

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
181 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

A practical synthesis of chiral amine precursors 3 and 4 and chiral diaza 18-crown-6 ethers 5, 6 and 7 starting from chiral amines are reported. The molecular recognition of these chiral crown ethers for amino acids potassium and sodium salts has been characterized by UV-vis. The selectivity order is Phe>Thr>Ala. In the case of 6 the cavity of the macrocycle plays an important role in recognition.

πŸ“œ SIMILAR VOLUMES

Enantioselective transport and liquid–li
Enantioselective transport and liquid–liquid extraction of amino acids as their potassium and sodium salts by optically active diaza-18-crown-6 ethers
✍ Nadir Demirel; Yasemin Bulut; Halil HoşgΓΆren πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 212 KB πŸ‘ 1 views

## Abstract Complexation of amino acids as their sodium and potassium salts by optically active diaza crown ethers has been investigated in transport across bulk liquid membranes containing the carriers and in extraction experiments. The observed enantioselectivity was achieved by (noncovalent) ste