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Synthesis of Chiral Chromans by the Pd-Catalyzed Asymmetric Allylic Alkylation (AAA): Scope, Mechanism, and Applications

✍ Scribed by Trost, Barry M.; Shen, Hong C.; Dong, Li; Surivet, Jean-Philippe; Sylvain, Catherine


Book ID
120194217
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
445 KB
Volume
126
Category
Article
ISSN
0002-7863

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A family of novel ferrocenylphosphine-amidine ligands derived from (R)-(S)-PPFNH 2 -R 5 was applied to the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylprop-2-en-1-yl acetate 8a or pivalate 8b with dimethyl malonate. Up to 94% e.e. was achieved when ligand 6b was used.