Synthesis of chiral acetic acid by chirality transfer from D-glucose
β Scribed by Kobayashi, Koji; Kakinuma, Katsumi; Floss, Heinz G.
- Book ID
- 126834023
- Publisher
- American Chemical Society
- Year
- 1984
- Tongue
- English
- Weight
- 284 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
A simple procedure for the synthesis of chiral acetic acids has been developed. The key step is an enzymatic exchange reaction which introduces 'H from 'H-labeled water into ethane I ,2diol. The method involves no resolution of racemic intermediates and the products are of high specific radioactivit
## Abstract The condensation of protected and unprotected 3βketoglucose (1) with hydrazines to 4βpyrazolols has been investigated. 3β (5) and 5β(Dβ__erythro__β1,2,3βtrihydroxypropyl)β4βpyrazolol (4) were obtained from 1 in high yield, as a mixture of these two isomers. A regioselective route starti
A facile synthetic method of chiral glycine and a new access to chiral acetic acid based on a concept of chirality transfer from glucose are described. Recently, we demonstrated usefulness of a technique consisting of the stereospecific chiral labeling of a prochiral methylene group by deuterium and