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Synthesis of catechol estrogens by human uterus and leiomyoma

✍ Scribed by Vangala V.R. Reddy; P. Hanjani; R. Rajan


Book ID
119481463
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
335 KB
Volume
37
Category
Article
ISSN
0039-128X

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Catechol estrogens, such as 2-hydroxyestriol, 2-hydroxyestradiol, and 2-hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 X 10(-6)M. Catechol estrogens lose approximately half of their inhibitory potency if the C-2 hydroxyl groups