β Scribed by W.T. Stolle; R.S.P. Hsi
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A new antibacterial agent gemifloxacin was labelled with carbonβ14 for studies of pharmacokinetics and metabolism, the label was located in position 3 of the quinolone ring system. The overall radiochemical yield of the 14βstep synthesis, starting from [2β^14^C]sodium acetate was 16.6%,
## Abstract Cytochrome P450 (CYP) enzymes are responsible for much of the phase I oxidative metabolism observed __in vivo__. Many important pharmaceutical compounds are metabolized by CYP. Coβadministration of a drug with another agent can alter the efficacy or the toxicity, especially in cases whe
## Abstract The syntheses of [^14^C] labelled antioxidants are described. We developed an efficient synthetic methodology to prepare a series of labelled amides with antioxidant activity, starting from [^14^C] KCN and alkyl or aryl halides. By a combination of nucleophilic displacement of halides b