The synthesis of (E)-5-(3-(2-(7-~hloroquinolin-2-yl)ethenyl)-phen~l)-[5-~~C]-4,6-dith~anonane dicarboxylic acid N.Ndimethylamide (I1 4C]MK-571), a high-allinity LTD4 antagonist , from sodium [ l 4C]cyanide via a five step sequence is described. Condensation of 3-[14C]cyanobenzaldehyde with 7-chloroq
Synthesis of carbon-14 labeled leukotriene antagonist SK&F 104353
โ Scribed by Arthur Y. L. Shu; Anthony J. Villani; J. Richard Heys
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- French
- Weight
- 429 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0022-2135
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๐ SIMILAR VOLUMES
Two lqC-labelled leukotriene receptor antagonists were prepared from two aryl bromides and potassium [ 14C]cyanide. cyanide was converted to copper(1) [L4C]cyanide and was subsequently used to displace the bromine atom from two dry1 bromides, 2-dodecylbromobenzene and 2-(8-phenyloctyl)bromobenzene.
## Abstract As asymmetric route to [^14^C]ฮฒโhydroxycompactin 1 bearing the (__S__)โ2โmethylโ[1โ^14^C]butanoate side chain has been developed. Methylation of [Nโ[1โ^14^C]butyrylโ4โ(__S__)โphenylmethylโ2โoxazolidinone 4 afforded a 95:5 mixture of diastereomeric [Nโ(__S,R__)โ2โmethylโ[1โ^14^C]butyryl]
S W 86002, 6-(4-f luorophenyl) -5-(4-pyridyl) -2,3-dihydroimidazo[2,l-b] thiazole, was synthesized labeled pith carbon-14 at C-1 or 14-2,3 using either [ C] thiourea or 1,2-dibromo [ C 3 ethane, respectively. The synthetic route, invogving the condensation of an asymmetric benzoin with thiourea foll
## Abstract Synthesis of a carbonโ14 labeled trifluoromethoxy group has been accomplished using the stepwise oxidative fluorinationโdesulfurization of a readily prepared [^14^C]xanthate (**5**). This novel labeling procedure allowed a rapid synthesis of substance P antagonist candidate **1** that a