Synthesis of c-18-functionalized c-nor-d-homosteroid by hypoiodite reaction
β Scribed by Hiroshi Suginome; Norio Sato; Tadashi Masamune
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 202 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
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For the purpoao of the qnthesisof eteroidalalkaloid ~oeeeaing unaeual C-nor-D-home ring ayater, we have ayatheeized, as an intermediate for the synthesis, a large number of C-nor-D-homosteroida from l24aygenated 0-8.~ Recently, Johnnoon and Ranck2 bare degraded the hetero-
The retinal analogues ( 13Z)-13-bromo-13-desmethylretinal (3) and ( 13E)-20,20,20-trifluororetinal (4) have been efficiently synthesized using the palladium-catalyzed cross-coupling of boronic acid 8 and electrophiles 9 and 10, respectively. For the first analogue, the coupling of 8 and the gem-dibr