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Synthesis of Building Blocks for Solid-Phase Introduction of Diethylenetriaminepentaacetic Acid (DTPA) to Oligonucleotides and Oligopeptides

✍ Scribed by Peuralahti, Jari; Jaakkola, Lassi; Mukkala, Veli-Matti; Hovinen, Jari


Book ID
115513245
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
125 KB
Volume
17
Category
Article
ISSN
1043-1802

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Synthesis of Nα-Boc-Nε-tetrabenzyl-DTPA-
✍ Dr John S. Davies; Loai Al-Jamri 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB

## Abstract Two building blocks, Boc‐Lys(Bn~4~‐DTPA)‐OH and Fmoc‐Lys($\hbox{Bu}^{\rm t}\_{4}$‐DTPA)‐OH have been synthesized via the acylation of the ε‐amino group of __N__^α^‐protected lysine, using suitably protected tetra‐esters of diethylene triamine pentaacetic acid (DTPA), a ligand with wide