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Amino Acid Building Blocks for Fmoc Solid-Phase Synthesis of Peptides Phosphocholinated at Serine, Threonine, and Tyrosine

โœ Scribed by Albers, Michael F.; Hedberg, Christian


Book ID
120021960
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
687 KB
Volume
78
Category
Article
ISSN
0022-3263

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During solid-phase peptide synthesis (SPPS) the three nitrogen atoms of the guanidine group of Arg (Figure 9.1), being strongly nucleophilic, are prone to alkylation and subsequent Orn (ornithine) formation upon base-mediated decomposition [1], and therefore need to be protected. However, in common