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Synthesis of Boronic Acid Analogues of α-Amino Acids by Introducing Side Chains as Electrophiles

✍ Scribed by Jagannathan, Sharada; Forsyth, Timothy P.; Kettner, Charles A.


Book ID
121370030
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
84 KB
Volume
66
Category
Article
ISSN
0022-3263

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Synthesis of 2,6-Disubstituted Piperidin
✍ Damien Boeglin; Annie Heitz; Jean Martinez; Jean-Alain Fehrentz 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

## Abstract A straightforward synthesis of 2,6‐disubstituted piperidines bearing α‐amino acid side‐chains was developed. Synthesis was based on a Horner−Wadsworth−Emmons condensation of a β‐ketophosphonate derived from an α‐amino acid residue with a β‐homologated aldehyde of an __N__‐protected amin