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Synthesis of Biologically Active Peptide Nucleic Acid−Peptide Conjugates by Sortase-Mediated Ligation

✍ Scribed by Pritz, Stephan; Wolf, Yvonne; Kraetke, Oliver; Klose, Jana; Bienert, Michael; Beyermann, Michael


Book ID
117989257
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
171 KB
Volume
72
Category
Article
ISSN
0022-3263

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## Abstract Peptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or D