Synthesis of biologically active N2-amine adducts of 2′-deoxyguanosine

✍ Scribed by Radha R Bonala; Irina G Shishkina; Francis Johnson

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 147 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01196-5

✦ Synopsis

Several biologically important N 2 -adducts of 2 H -deoxyguanosine (dG) that previously were dicultly accessible, have been synthesized directly by means of the Buchwald±Hartwig reaction. The reaction employed in each case involves the coupling of 2 H -deoxy-2-bromoinosine with the appropriate amine. Deprotection in all cases gave good yields of the desired 2-alkylated or -arylated deoxynucleoside.