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Synthesis of Bioactive 2-Aza-Analogues of Ipecac and Alangium Alkaloids

✍ Scribed by Michael Kölzer; Kerstin Weitzel; H. Ulrich Göringer; Eckhard Thines; Till Opatz

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
440 KB
Volume
5
Category
Article
ISSN
1860-7179

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✦ Synopsis

Polycyclic alkaloids with potent eukaryotic cytotoxicity have been isolated from the tropical shrubs Cephaelis ipecacuanha and Alangium lamarckii. [1,2] Their skeleton features an invariable benzoquinolizidine core, which is linked to a bi-or tricyclic unit by a methylene bridge (Figure 1).

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