Synthesis of aza-muricatacin: an analogue of the bioactive muricatacin an acetogenin of Annonaceae
✍ Scribed by Isabelle Baussanne; Oliver Schwardt; Jacques Royer; Marianne Pichon; Bruno Figadère; André Cavé
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 240 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract An efficient stereoselective total synthesis of (+)‐(4__S__,5__S__)‐muricatacin was accomplished in good yields from inexpensive, commercially available chemicals ((+)‐diethyl tartrate (DET) and undecan‐1‐ol) by utilizing __Mitsunobu__ and __JuliaKocienski__ reactions, __Wittig__ homol
A short, efficient and highly stereoselective synthesis of (-)-(R,R)-muricatacin is reported. The key steps include a highly diastereoselective reduction of a b-ketosulfoxide to a b-hydroxy sulfoxide, regio-and stereoselective bromohydration of an olefin employing the sulfinyl group as an internal n