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Synthesis of bifunctional cationic compound for gene delivery

✍ Scribed by Tan Ren; Guisheng Zhang; Dexi Liu

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
97 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Bifunctional cationic compound carrying trivalent galactosides as the cell targeting ligand and DAB-dendr-(NH 2 ) 8 (generation 2.0) as the DNA binding domain was synthesized for gene delivery to hepatocytes. DAB-dendr-(NH 2 ) 4 (generation 1.0) conjugated with a hydrocarbon chain was used as a scaffold for the attachment of three galactosides, while the other hydrocarbon end was linked with DAB-dendr-(NH 2 ) 8 (generation 2.0) through a carbamate bond. This design provided an effective entry for the synthesis of a polyamine compound having the cell targeting galactosyl ligand. Preliminary in vitro transfection results demonstrated that the bifunctional cationic compound could effectively deliver the gene into HepG2 cells.

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