Efficient solid-phase synthesis of perfluoroalkylated dimerizable cationic detergents for gene delivery

✍ Scribed by Nicolas Guilloteau; Loïc Le Gourriérec; Karine Fabio; Christophe Di Giorgio; Jacques Greiner; Pierre Vierling

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 151 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.11.072

✦ Synopsis

A new straightforward solid-phase synthesis of perfluoroalkylated dimerizable detergents used as gene delivery systems is presented. This route using Fmoc-Cys(SASRIN TM_Ò )-OH resin as solid support affords the target products in almost quantitative yields and high purity.