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Synthesis of bicyclic azacompounds (3-dimethylcarbamoyloxyphenyl) substituted as acetylcholinesterase inhibitors

✍ Scribed by Anna Borioni; Maria Rosaria Del Giudice; Carlo Mustazza; Franco Gatta

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
1020 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

This paper describes the synthesis of some bicyclic 2‐(3‐dimethylcarbamoyloxyphenyl) substituted azaderivatives, obtained from 1,4‐ and 1,5‐diketones, which were cyclized with ammonium acetate, methylamine and by reductive amination. Corresponding 3‐substituted derivatives were instead prepared by reaction of 1,5‐ketoesters with formamide. The carbamates were tested as in vitro acetylcholinesterase inhibitors.

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