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Synthesis of benzyl and tert-butyl 3-(2-methoxycarbonylethyl)-4-methylpyrrole-2-carboxylates from methyl 4-oxobutanoate

✍ Scribed by Martin A. Drinan; Timothy D. Lash


Book ID
112130873
Publisher
Journal of Heterocyclic Chemistry
Year
1994
Tongue
English
Weight
264 KB
Volume
31
Category
Article
ISSN
0022-152X

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## Abstract Both enantiomers of 2‐__tert__‐butyl‐2‐methyl‐1,3‐benzodioxole‐4‐carboxylic (TBMB) acid, which has a unique quaternary chiral center located on the acetal carbon, were prepared from a racemic ketone in which the carboxy group was replaced by a trifluoroacetyl group. First, reduction wit