New Synthesis of Alkyl 1-tert-Butyl-4,4-dimethyl-2,5-dioxo-pyrrolidine-3-carboxylate and Dialkyl 2-(1-tert-Butylcarbamoyl-1-methyl-ethyl)-malonates.
โ Scribed by Issa Yavari; Mohammad R. Hosseini-Tabatabaei; Azizollah Habibi
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 109 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Both enantiomers of 2โ__tert__โbutylโ2โmethylโ1,3โbenzodioxoleโ4โcarboxylic (TBMB) acid, which has a unique quaternary chiral center located on the acetal carbon, were prepared from a racemic ketone in which the carboxy group was replaced by a trifluoroacetyl group. First, reduction wit