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Synthesis of benzo(ij)cycl[3.3.2]azines via a palladium mediated cyclisation reaction

โœ Scribed by Michel Pfeffer; Marc A. Rotteveel


Book ID
104589093
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
167 KB
Volume
108
Category
Article
ISSN
0165-0513

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Microwave promoted synthesis of cycl[3.2
โœ Shyamalee Gogoi; Mandakini Dutta; Junali Gogoi; Romesh Chandra Boruah ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 549 KB

A microwave-promoted and base-catalyzed synthesis of cycl[3.2.2]azines is accomplished in water via a three-component reaction (3-CR) of 2-picoline, a-bromoacetophenone and alkyne. The extension of the methodology to the synthesis of steroidal and carbocyclic cycl[3.2.2]azine is also reported.