The nucleophilic ring opening of (R)-~-butyrolactone 2 with 2-thiophenethiolate is the key step in a straightforward stereospecific synthesis of keto sulfone 1, a precursor to carbonic anhydrase inhibitor M K-0507.
Synthesis of benzohetero[3, 2-a]pyrimidines using cyclic β-keto lactone as a building block
✍ Scribed by Raghunath B. Toche; Bhausaheb K. Ghotekar; Muddassar A. Kazi; Madhukar N. Jachak
- Book ID
- 106214123
- Publisher
- Springer Vienna
- Year
- 2008
- Tongue
- English
- Weight
- 268 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0026-9247
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