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β-butyrolactone as a chiral building block in organic synthesis: A convenient synthesis of MK-0507 keto sulfone

✍ Scribed by Orin Tempkin; Thomas J. Blacklock; J. Andrew Burke; Maria Anastasia

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 249 KB
Volume: 7
Category: Article
ISSN: 0957-4166
DOI: 10.1016/0957-4166(96)00350-3

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✦ Synopsis

The nucleophilic ring opening of (R)-~-butyrolactone 2 with 2-thiophenethiolate is the key step in a straightforward stereospecific synthesis of keto sulfone 1, a precursor to carbonic anhydrase inhibitor M K-0507.

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