𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of benzofurans through coupling of dienylacetylenes with carbene complexes: total synthesis of egonol

✍ Scribed by Jianwei Zhang; Yi Zhang; Yanshi Zhang; James W Herndon

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
265 KB
Volume
59
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.

✦ Synopsis

The reaction of various carbene complexes with dienylacetylenes has been examined. The reaction has been used as the cornerstone for the preparation of the nor-neolignan natural product egonol in five steps from readily available components. In most examples of the carbene -alkyne coupling, the reaction proceeds to form benzofuran derivatives. In the case of one highly functionalized terminal alkyne, a competing rearrangement/cyclization process occurs in preference to the carbene coupling process. The use of silylated alkynes subverts this process.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Highly Effective To
ChemInform Abstract: Highly Effective Total Synthesis of Benzofuran Natural Product Egonol.
✍ Da Hye Choi; Jung Woon Hwang; Hyun Suck Lee; Deok Mo Yang; Jong-Gab Jun πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons βš– 28 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v