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Synthesis of benzo[c]phenanthrene dihydrodiols

✍ Scribed by M. Croisy-Delcey; Y. Ittah; D.M. Jerina

Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
259 KB
Volume
20
Category
Article
ISSN
0040-4039

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✦ Synopsis

Unlike most other alternant polycyclic aromatic hydrocarbons which are carcinogenic, benzo[c]phenanthrene has a "fjord region" instead of a "bay region". For this reason, we have synthesized the three metabolically possible trans 1,2-, 3,4-, and 5,6-dihydrodiols to test them for carcinogenic activity.

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