Synthesis of atropisomeric 1-phenylpyrrole-derived amino alcohols: New chiral ligands
✍ Scribed by Ferenc Faigl; Béla Mátravölgyi; Áron Szöllősy; Mátyás Czugler; Gábor Tárkányi; Károly Vékey; Miklós Kubinyi
- Book ID
- 112049479
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 1010 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0899-0042
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📜 SIMILAR VOLUMES
An efficient three step process for the synthesis of chiral, nonracemic methyleneaziridines derived from homochiral [3-amino alcohols is described. Methyleneaziridines 4a-e produced using this chemistry have been shown to possess high enantiomeric purities (>\_ 95%ee).
The easily prepared chiral tertiary amino alcohol 1a was found to catalyze the reaction of alkynylzinc reagents with various aldehydes to generate chiral propargylic alcohols with moderate-to-good enantioselectivities. The mechanism of the reaction is also discussed in this Letter. A novel theoretic
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