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Synthesis of aspartame precursor with an immobilized thermolysin in tert-amyl alcohol

โœ Scribed by Takeshi Nagayasu; Masamitsu Miyanaga; Takaaki Tanaka; Takaharu Sakiyama; Kazuhiro Nakanishi


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
631 KB
Volume
43
Category
Article
ISSN
0006-3592

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๐Ÿ“œ SIMILAR VOLUMES


Synthesis of aspartame precursor with an
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N-(benzyloxycarbony1)-L-aspartyl-L-phenylalanine methyl ester, a precursor of the synthetic sweetener, aspartame, was synthesized from N-(benzyloxycarbony1)-L-as- partic acid and L-phenylalanine methyl ester with an immobilized thermolysin (EC 3.4.24.4) in the mixed organic solvent system of tert-am

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N-(Benzyloxycarbonyl)-L-asparty-L-phenylalanine methyl ester, the precursor of the synthetic sweetener aspartame, was continuously synthesized in an immobilized thermolysin plug-flow type reactor at 25 degrees C with the substrates (N-benzyloxycarbonyl-L-aspartic acid and L-phenylalanine methyl este