Synthesis of arylpiperazines via palladium-catalyzed aromatic amination reaction with unprotected piperazines
β Scribed by Shu-Hai Zhao; Aubry K. Miller; Jacob Berger; Lee A. Flippin
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 204 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Reaction of a series of bicyclic bromoarenes with N-tert-butoxycarbonylpiperazine (N-Boc-piperazine) under palladium-catalysed coupling conditions followed by routine removal of the Boc group with trifluoroacetic acid in dichloromethane gave the corresponding arylpiperazines in moderale to good yiel
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract The new, practical process starts from oβhalophenylβsubstituted substrates (I) and (IV) and allows the formation of 2 CβN bonds in one pot.