Synthesis of arylpiperazines via palladium-catalysed aromatic amination reactions of bromoarenes with N-tert-butoxycarbonylpiperazine

✍ Scribed by Frank Kerrigan; Claire Martin; Gerard H. Thomas

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 206 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00179-8

✦ Synopsis

Reaction of a series of bicyclic bromoarenes with N-tert-butoxycarbonylpiperazine (N-Boc-piperazine) under palladium-catalysed coupling conditions followed by routine removal of the Boc group with trifluoroacetic acid in dichloromethane gave the corresponding arylpiperazines in moderale to good yield.