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Synthesis of Aryl Glycines by the α Arylation of Weinreb Amides

✍ Scribed by Sebastian Hirner; Olaf Panknin; Magnus Edefuhr; Peter Somfai


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
332 KB
Volume
120
Category
Article
ISSN
0044-8249

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✍ Sebastian Hirner; Donata K. Kirchner; Peter Somfai 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB

## Abstract An efficient and diastereoselective synthesis of α‐amino acids from readily available starting materials has been developed. The key feature of this reaction is an umpolung of a glycine‐derived enolate, providing an alternative approach for the synthesis of α‐amino acids. (© Wiley‐VCH V