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Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes

✍ Scribed by Tuccinardi, Tiziano; Bertini, Simone; Martinelli, Adriano; Minutolo, Filippo; Ortore, Gabriella; Placanica, Giorgio; Prota, Giovanni; Rapposelli, Simona; Carlson, Kathryn E.; Katzenellenbogen, John A.


Book ID
115513292
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
397 KB
Volume
49
Category
Article
ISSN
0022-2623

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✍ Chung K. Rhee; Kun Chae; Louis A. Levy; Kenneth S. Korach πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 207 KB

Synthesis of fluorinated DES and hexestrol derivatives starting from 4-methoxybenzaldehyde is described. The structures of the fluorinated compounds were characterized by NMR. The fluorinated DES derivatives bind to the mouse uterine cytosol estrogen receptor with high affinity.