✦ LIBER ✦

Synthesis and estrogen receptor binding of fluorinated diethylstilbestrol derivatives

✍ Scribed by Chung K. Rhee; Kun Chae; Louis A. Levy; Kenneth S. Korach

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 207 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(94)00472-r

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✦ Synopsis

Synthesis of fluorinated DES and hexestrol derivatives starting from 4-methoxybenzaldehyde is described. The structures of the fluorinated compounds were characterized by NMR. The fluorinated DES derivatives bind to the mouse uterine cytosol estrogen receptor with high affinity.

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