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Synthesis of Analogues of GABA. XIV. Synthesis and Activity of Unsaturated Derivatives of 5-Aminopentanoic Acid (d-Aminovaleric Acid)

✍ Scribed by Allan, RD; Dickenson, HW; Johnston, GAR; Kazlauskas, R; Tran, HW

Book ID
121349257
Publisher
Commonwealth Scientific and Industrial Research Organisation Publishing
Year
1985
Tongue
English
Weight
295 KB
Volume
38
Category
Article
ISSN
0004-9425

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## Abstract The synthesis of a new radioligand, which binds with high selectivity and affinity (K~D~ = 7.4 nM) to the GABA‐B receptor, is described. A Wittig‐Horner approach was employed to prepare an unsaturated protected intermediate (6), suitable for tritiation and deprotection.