Synthesis of an α-amino-β-thiolactam
✍ Scribed by Kenneth R. Henery-Logan; H. P. Knoepfel; J. V. Rodricks
- Book ID
- 112121775
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1968
- Tongue
- English
- Weight
- 104 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0022-152X
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AbstractÐSeveral types of achiral N,N-dibenzyl-a,b-unsaturated thioamides were subjected to X-ray crystallographic analysis, and it was revealed that methylcrotonthioamide and 1-cyclohexenecarbothioamide provided chiral crystals. The absolute con®guration determined by anomalous scattering method co
threo-a-Dibensylamino-B-hydroxyesters (2) have been synthesised with high diastereoselectivity through the NaBH reduction of a-dibenzylamino-B-oxoesters (4) and then tranformed into threo-a-amino-B-hydroxyac?ds. a-Amino-B-hydroxyacids are derivatives of primary importance both as enzymatic inhibito