Synthesis of an analogue of the phospholipid platelet activation factor from a natural ethanolamine plasmalogen
โ Scribed by V. I. Kulikov; A. A. Dergousov
- Book ID
- 104828301
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 325 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0009-3130
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๐ SIMILAR VOLUMES
A novel stereospecific synthesis of biologically active ether-phospholipids is reported. Ether phospholipids are among the most potent biologically active phospholipid derivatives.ls2 Naturally occuring as membrane-components, a number of l-sn-alkoxyglycero-phosphorylcholines have been shown to be r
Acetyl glyceryl ether phosphorylcholines, platelet-activating factors (1 and 21, were efficiently synthesized in a stereochemically unambiguous manner starting from D-and L-tartaric acids as the chiral synthons. Since its isolation and characterization by Hanahan and his co-workers in
The multistep synthesis of a platelet activating factor (PAF) analog having a reactive aldehyde group at the ~-end of the sn-I position is described. A novel ozonolysis of a double bond was employed to generate the aldehyde group in high yield under mild conditions. The aldehyde group was generated