Synthesis of an amphiphilic aldehyde using as a key step the condensation of a lipophilic glyoxylic acid amide derivative with tris(hydroxymethyl)aminomethane

✍ Scribed by Dominique Bonnet; Pascal Joly; Hélène Gras-Masse; Oleg Melnyk

• Book ID: 104230118
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 83 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00032-6

✦ Synopsis

Spontaneous condensation of a glyoxylic acid amide derivative incorporating a palmitoyl group with tris(hydroxymethyl)aminomethane followed by Dess-Martin oxidation led to an heterocyclic amphiphilic aldehyde, which was successfully engaged in hydrazone formation in partial aqueous media.