In order to assess a novel strategy for catalytic activation of a new prodrug of doxorubicin, a new hapten has been designed and prepared, which can be used to induce an immune response from which catalytic antibodies (cAbs) may be produced.
Synthesis of an aminoalcohol hapten for the generation of catalytic antibodies
✍ Scribed by José Flórez-Álvarez; Keith Brocklehurst; Gerard Gallacher; Marina Resmini
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 73 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The conditions under which the reduction of a-hydroxy azides by triphenylphosphine to aziridines is diverted to produce the corresponding aminoalcohol have been established.
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An extension of the transition state analogue (TSA) hapten approach for the elicitation of catalytic antibodies for acyl-transfer reactions is described. It is based on the enlistment of phosphorodithioate 1 as a stable mimic of the putative tetrahedral intermediate (TI-) formed during the base-cata