The conditions under which the reduction of a-hydroxy azides by triphenylphosphine to aziridines is diverted to produce the corresponding aminoalcohol have been established.
Synthesis of a new hapten for generating catalytic antibodies that activate doxorubicin prodrugs
✍ Scribed by Carlos Jiménez; Alfonso Tramontano
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 75 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
In order to assess a novel strategy for catalytic activation of a new prodrug of doxorubicin, a new hapten has been designed and prepared, which can be used to induce an immune response from which catalytic antibodies (cAbs) may be produced.
📜 SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
An extension of the transition state analogue (TSA) hapten approach for the elicitation of catalytic antibodies for acyl-transfer reactions is described. It is based on the enlistment of phosphorodithioate 1 as a stable mimic of the putative tetrahedral intermediate (TI-) formed during the base-cata
Endotoxin / Immunotherapy /