Enantio- and diastereoselective synthesi
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Barry Lygo; John Crosby; Terence R. Lowdon; Philip G. Wainwright
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Article
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1997
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Elsevier Science
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French
⚖ 316 KB
An enantio-and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine is reported. Key steps involve the use of the Sharpless dihydroxylation protocol to induce asymmetry, and stereodivergent cyclisations of the resulting diol to form the quinuclidine