The anomeric hydroxyl group of various furanose andpyranose hemiacetals can be replaced by a fluorine, chlorine, bromine or iodine atom under neutral conditions using haloenamines.
Synthesis of alkyl halides under neutral conditions
✍ Scribed by François Munyemana; Anne-Marie Frisque-Hesbain; Alain Devos; Léon Ghosez
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 224 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Primary and secondary alcohols are efficiently converted to the halides under neutral conditions.
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## Abstru: Lipases from Candida cylindracea and from Pseudomonas fluofescens efficiently catalyse the benzyl to alkyl transesterification in organic solvents under mild conditions in nearly quantitative yields.