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Synthesis of Acyclic Bis-vinyl Pyrimidines: A General Route to d4T via Metathesis.

✍ Scribed by D. F. Ewing; V. Glacon; G. Mackenzie; D. Postel; C. Len

Book ID
101947214
Publisher
John Wiley and Sons
Year
2003
Weight
18 KB
Volume
34
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

A novel approach to unsaturated acyclic
A novel approach to unsaturated acyclic nucleoside analogues and the first synthesis of d4T by ring closure metathesis
✍ David Ewing; Virginie GlaΓ§on; Grahame Mackenzie; Denis Postel; Christophe Len πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 55 KB

enyloxy]prop-2-enyl}cytosine have been prepared in good yield from uridine and 5-methyluridine by periodate cleavage followed by a double Wittig reaction which introduces two vinyl groups. The thymine derivative underwent ring closure metathesis to give a novel synthesis of d4T.